The contribution of TMC1 to adaptation of mechanoelectrical transduction channels in cochlear outer hair cells
نویسندگان
چکیده
منابع مشابه
Distortion product emissions from a cochlear model with nonlinear mechanoelectrical transduction in outer hair cells.
A model of cochlear mechanics is described in which force-producing outer hair cells (OHC) are embedded in a passive cochlear partition. The OHC mechanoelectrical transduction current is nonlinearly modulated by reticular-lamina (RL) motion, and the resulting change in OHC membrane voltage produces contraction between the RL and the basilar membrane (BM). Model parameters were chosen to produce...
متن کاملPutting ion channels to work: mechanoelectrical transduction, adaptation, and amplification by hair cells.
As in other excitable cells, the ion channels of sensory receptors produce electrical signals that constitute the cellular response to stimulation. In photoreceptors, olfactory neurons, and some gustatory receptors, these channels essentially report the results of antecedent events in a cascade of chemical reactions. The mechanoelectrical transduction channels of hair cells, by contrast, are co...
متن کاملStochastic resonance in the mechanoelectrical transduction of hair cells.
In transducing mechanical stimuli into electrical signals, at least some hair cells in vertebrate auditory and vestibular systems respond optimally to weak periodic signals at natural, nonzero noise intensities. We understand this stochastic resonance by constructing a faithful mechanical model reflecting the hair cell geometry and described by a nonlinear stochastic differential equation. This...
متن کاملTmc1 Point Mutation Affects Ca2+ Sensitivity and Block by Dihydrostreptomycin of the Mechanoelectrical Transducer Current of Mouse Outer Hair Cells.
UNLABELLED The transduction of sound into electrical signals depends on mechanically sensitive ion channels in the stereociliary bundle. The molecular composition of this mechanoelectrical transducer (MET) channel is not yet known. Transmembrane channel-like protein isoforms 1 (TMC1) and 2 (TMC2) have been proposed to form part of the MET channel, although their exact roles are still unclear. U...
متن کاملTmc1 Point Mutation Affects Ca Sensitivity and Block by Dihydrostreptomycin of the Mechanoelectrical Transducer Current of Mouse Outer Hair Cells
(2016) Tmc1 point mutation affects Ca2+ sensitivity and block by dihydrostreptomycin of the mechanoelectrical transducer current of mouse outer hair cells. This document is made available in accordance with publisher policies and may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the U...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2019
ISSN: 0022-3751,1469-7793
DOI: 10.1113/jp278799